Prevention and Management of Wound Procedural Pain Management in Adult Patients with Open Wounds: Integration of the Latest Clinical Evidence

Honglin Yao,1 Fan Yang,1 Xianghong Ye,1 Yang Yang,1 Jiaqi Li2 1Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, People’s Republic of China; 2Operation Room, Hainan General Hospital, Haikou, People’s Republic of ChinaCorrespondence: Jiaqi Li, Email ljqnju123@163.comPurpose: To retrieve, evaluate, and integrate the best available evidence on prevention and management of wound procedural pain management in patients with open wounds, providing evidence-based guidance for clinical practice.Patients and Methods: Following the “ 6S” pyramid model, we systematically searched guideline websites, professional association websites, and databases for guidelines, clinical decision aids, expert consensus statements, evidence summaries, recommended practices, and systematic reviews related to wound procedural pain management in patients with open wounds. The search period was from the establishment of the database to July 2025. Two researchers independently conducted literature quality assessment, evidence extraction, and synthesis.Results: A total of 23 documents were included: 5 guidelines, 1 expert consensus, 3 recommended practices, 3 clinical decisions, 6 evidence summaries, and 5 systematic reviews. Thirty-two best evidence statements were summarized across six aspects: pain assessment and documentation, education and training, dressing selection and replacement, wound cleansing, debridement, and negative pressure therapy, pharmacological intervention strategies, and non-pharmacological intervention strategies.Conclusion: This study reviews the best available evidence on managing procedural pain in open wounds. It offers guidance on the principles of pain management, standardization of procedural techniques, and the timely application of analgesic, emphasizing the importance of pain awareness. The research serves as a reference for developing specialized pain management protocols to improve wound care quality.Keywords: wound procedural pain, open wounds, evidence-based nursing, clinical evidence