Die Stabilität des inaktiven X-Chromosoms im Alter

mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) 2026 Thesis Open access

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Authors: Sarah Weiler
Cited by: 0

Abstract

To balance X-linked gene dosage between sexes, one female X chromosome is inactivated, yet some genes escape silencing, leading to higher expression in women. This allele-specific multi-omics analysis in a polymorphic mouse model revealed a substantial increase in escape and chromatin accessibility during aging, particularly at distal chromosome regions. Age-specific escape of disease-relevant genes lays the groundwork for future research on sex bias in age-related diseases.

Fields of Study & Subjects

Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities Genomics and Chromatin Dynamics Epigenetics and DNA Methylation

Publication details

Journal / source
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)
Publication date
15 January 2026
Language
EN
Document type
Thesis