Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity

OSF Preprints (OSF Preprints) 2026 Preprint Open access

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Authors: Francesca N Venditti, Forest M. White, Roger J. Davis, Jessica B. Spinelli, Alex Toker, Jeffrey C Davis, Matthew G. Vander Heiden, Tigist Y. Tamir, Annie X Li, Alekhya Abhiram Kandoor, S Trojan, Paula Vo
+6 more Shreya Chaudhary, Alissandra L. Hillis, Cameron T. Flower, Rachit S Mukkamala, Yufei Cui, Norman J. Kennedy
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Abstract

By employing a multi-disciplinary approach we stratify structural features of phosphorylation sites on metabolic enzymes, map the systems level changes induced by obesity, identify key pathways with sex specific phosphoproteomic responses, and validate the functional role of phosphorylation sites for select enzymes.

Fields of Study & Subjects

Advanced Proteomics Techniques and Applications Bioinformatics and Genomic Networks Protein Tyrosine Phosphatases

Publication details

Journal / source
OSF Preprints (OSF Preprints)
Publication date
18 January 2026
Document type
Preprint