Non-Arteritic Ischaemic Optic Neuropathy Associated with Semaglutide Use.
Abstract
Presentation: A 50-year-old obese male with non-insulin dependent diabetes mellitus (NIDDM) taking Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA) presented with sudden, painless vision-loss from his right eye. Diagnosis: Right eye visual acuity was 6/24. There was Frisen grade IV optic nerve head (ONH) oedema. This was confirmed at imaging with ocular coherence tomography (OCT). The patient was diagnosed with non-arteritic anterior ischaemic optic neuropathy. Treatment: Semaglutide was ceased. Discussion: GLP-1RAs such as Semaglutide are being increasingly recognised as a potential risk factor for NAION. A case such as this has not yet been reported in Ireland.
Fields of Study & Subjects
Drug-Induced Ocular Toxicity
Glaucoma and retinal disorders
Retinal Diseases and Treatments
Publication details
- Journal / source
- PubMed
- Volume
- 119
- Issue
- 1
- Pages
- 13–13
- Publication date
- 22 January 2026
- Language
- EN