Combination of Antidepressants and Chemotherapeutic Agents to Overcome P-glycoprotein-Mediated Resistance in cancer patients A Systematic Review
Abstract
This systematic review examines preclinical and clinical studies evaluating antidepressants as modulators of P-glycoprotein–mediated multidrug resistance in cancer. Eligible studies assess the effects of antidepressants combined with chemotherapeutic agents on P-gp activity, drug accumulation, and chemosensitivity across different cancer models. Findings are qualitatively synthesized.
Fields of Study & Subjects
Drug Transport and Resistance Mechanisms
Pharmacogenetics and Drug Metabolism
Antibiotic Resistance in Bacteria
Publication details
- Journal / source
- OSF Preprints (OSF Preprints)
- Publication date
- 26 January 2026
- Document type
- Preprint