Erforschung und Adressierung der MCT8-Defizienz durch MCT8/OATP1C1-dKO-Gehirntranskriptomik, neuartige MCT8-Cre Linien, und Peptid-TH-Chimären

mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) 2026 Thesis Open access

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Authors: Anna Molenaar
Cited by: 0

Abstract

Deficient transport of thyroid hormones due to mutations in the transporter MCT8 lead to severe neurodevelopmental disorders summarized as the Allan-Herndon-Dudley syndrome. The cell-biological consequences of the deficient thyroid hormone transport were investigated by single nucleus RNA sequencing of the cortex of the MCT8/OATP1C1 mouse model. For the targeted characterization of MCT8-expressing cells an MCT8-CreERT2 mouse line was generated and validated.

Fields of Study & Subjects

Thyroid Disorders and Treatments Drug Transport and Resistance Mechanisms Genetics and Neurodevelopmental Disorders

Publication details

Journal / source
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)
Publication date
2 February 2026
Language
EN
Document type
Thesis