Sonidegib Therapy for Locally Advanced Basal Cell Carcinoma in an Elderly Patient: A Case Report

Yuyu Deng,1– 5 Pingxiu He,1– 5 Changxia Li,1– 5 Guolan Li,1– 5 Xiaohua Tao1– 5 1Dermatology Department, Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 2Dermatology Department, Jiangxi Provincial Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 3Dermatology Department, Candidate Branch of National Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 4Dermatology Department, Dermatology Institute of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 5Dermatology Department, The Affiliated Dermatology Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of ChinaCorrespondence: Xiaohua Tao, Email taoxiaohua@126.comAbstract: We report a case of locally advanced basal cell carcinoma (BCC) of the nose successfully treated with oral sonidegib. An 87-year-old man presented with a pruritic brown papule in the right nasolabial fold, progressively enlarging for > 10 years and ulcerated for 7 years. Histopathology confirmed nodular BCC with tumor thickness ≥ 6 mm. Sonidegib (200 mg daily) was initiated, and a complete resolution was achieved after 5 months. No recurrence or significant adverse effects were observed 4 months post-treatment.Keywords: Sonidegib, therapy, locally advanced, basal cell carcinoma