Efficacy and Safety of Ustekinumab for Pediatric and Adult Crohn's Disease: An Umbrella Review of Systematic Reviews and Meta-Analyses
Abstract
Ustekinumab is an established biologic therapy for Crohn’s disease (CD). While numerous systematic reviews (SRs) and meta-analyses (MAs) have synthesized evidence on its use, these reviews vary in scope, methodology, and conclusions, particularly when comparing pediatric and adult populations. An umbrella review is needed to comprehensively map, critically appraise, and synthesize this high-level evidence.
Fields of Study & Subjects
Inflammatory Bowel Disease
Psoriasis: Treatment and Pathogenesis
Ocular Diseases and Behçet’s Syndrome
Publication details
- Journal / source
- OSF Preprints (OSF Preprints)
- Publication date
- 5 February 2026
- Document type
- Preprint