Preparation and structural and dynamic characterization of biomolecules at the atomic level by means of cutting-edge biophysical and spectroscopic techniques for the study of biological processes at the molecular-level
Abstract
This thesis uses solution NMR spectroscopy to study the structure, dynamics, and interactions of the SARS-CoV-2 nucleocapsid protein. By analyzing different constructs of increasing complexity, it highlights the role of intrinsically disordered regions in mediating multivalent protein–polyanion interactions and dynamic conformational behavior.
Fields of Study & Subjects
Protein Structure and Dynamics
Advanced NMR Techniques and Applications
SARS-CoV-2 and COVID-19 Research
Publication details
- Journal / source
- Florence Research (University of Florence)
- Publication date
- 1 January 2026
- Language
- EN
- Document type
- Thesis