Changes in sputum viscoelastic properties and airway inflammation in primary ciliary dyskinesia are comparable to cystic fibrosis on elexacaftor/tezacaftor/ivacaftor therapy

MDC Repository (Max-Delbrueck-Center for Molecular Medicine) 2026 Dataset

Authors: M. Kirchner, P. Mertins
Cited by: 0

Abstract

ivacaftor (ETI) therapy. Methods: We measured and compared sputum rheology, inflammation markers and the proteome in 42 clinically stable adolescent and adult patients with PCD, 40 patients with CF with at least one F508del allele before and 3 months after initiation of ETI and 15 age-matched healthy controls. Results: Patients with PCD showed increased viscoelastic properties (G’ and G’’ P

Fields of Study & Subjects

Cystic Fibrosis Research Advances Genetic and Kidney Cyst Diseases Immunodeficiency and Autoimmune Disorders

Publication details

Journal / source
MDC Repository (Max-Delbrueck-Center for Molecular Medicine)
Publication date
12 January 2026
Document type
Dataset