Revisiting the Platelet-β-Cell Axis: Insights into How Platelet-Derived Mediators, Lipid Signaling, and DOC2B Pathways Converge to Drive β-Cell Dysfunction in Type 2 Diabetes.
Abstract
-sensitive mediator of insulin vesicle fusion. Revisiting this axis clarifies how thromboinflammation and lipotoxicity orchestrate β-cell failure and highlights emerging therapeutic targets for T2DM. This review introduces a novel integrative perspective linking platelet-derived mediators, lipid dysregulation, and DOC2B-mediated exocytotic failure as a unified model of β-cell dysfunction in T2DM.
Fields of Study & Subjects
Pancreatic function and diabetes
Diabetes Treatment and Management
Platelet Disorders and Treatments
Publication details
- Journal / source
- Europe PMC (PubMed Central)
- Volume
- 37
- Issue
- 1
- Pages
- 9–15
- Publication date
- 1 February 2026
- Language
- EN