Correlation between serum total bilirubin,albumin levels and cognitive function in first⁃episode drug⁃naïve patients with schizophrenia

ObjectiveTo investigate the correlation between peripheral non⁃enzymatic antioxidant levels,such as serum uric acid(UA),total bilirubin(TBIL),and albumin(ALB),and cognitive impairment in first⁃episode drug⁃naïve(FEDN) patients with schizophrenia(SZ).MethodsA total of 167 FEDN schizophrenia patients from the department of psychiatry,First Hospital of Shanxi Medical University,were enrolled as the case group from October 2022 to October 2024,along with 103 matched healthy volunteers as the control group.Fasting venous blood was collected to measure serum UA,TBIL,and ALB levels. Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).ResultsThe case group showed significantly lower serum ALB and TBIL levels compared to the healthy control group(P