Coexistence of Dual Chromosomal Abnormalities t(3;7) and t(9;22) in Case of B-Acute Lymphoblastic Leukemia: a Rare Genomic Profile with Diagnostic and Prognostic Challenges.

OBJECTIVES: Acute lymphocytic leukemia (ALL) is a hematologic malignancy marked by clonal growth of lymphoid precursors within the bone marrow, resulting in disrupted hematopoiesis. Chromosomal abnormalities provide valuable information on the development of ALL and serve as a key indicator of patient outcomes and treatment strategies. Numerous genetic abnormalities can be seen in ALL. Here, we described a case of a 15-year-old patient with B-ALL confirmed through biopsy and immunophenotyping. Conventional cytogenetic and FISH analysis showed t(3;7) with the presence of t(9;22). Translocation t(3;7) is rarely observed and is associated with a worse/ poor prognosis. Hence, the identification of such translocations in patients with B-ALL can aid in patient stratification, personalized medicine, and risk assessment.