Colistin-Associated Acute Kidney Injury in Burn Patients: Incidence, Associated Factors and Prognosis.
Abstract
Colistin is often essential in burn patients presenting infections caused by multidrug-resistant organisms. A retrospective study was conducted in the intensive burn care department in Tunisia over 14 months to assess prevalence and predictive factors of colistin-related acute kidney injury (AKI). Among 70 patients (mean age 34±13 years), 28.6% developed AKI, with onset at 5±2 days. Associated factors included total burned surface area >41% (OR=2.6), UBS score >58 (OR=6.8), metabolic acidosis at admission (OR=28) and contrast agent injection (OR=107). AKI was reversible in 40% of cases. Colistin-associated AKI remains a frequent complication in severely burned patients, and in cases of contrast agent use.
Fields of Study & Subjects
Acute Kidney Injury Research
Burn Injury Management and Outcomes
Chemotherapy-induced organ toxicity mitigation
Publication details
- Journal / source
- PubMed
- Volume
- 39
- Issue
- 1
- Pages
- 63–69
- Publication date
- 1 March 2026
- Language
- EN