Exploring Electroencephalographic Chronic Pain Biomarkers: A Mega-Analysis

Background: Chronic pain is associated with alterations in brain function, offering promising avenues for advancing diagnostic and therapeutic strategies. In particular, these alterations may serve as brain-based biomarkers to support diagnosis, guide treatment decisions and monitor clinical courses of chronic pain. Methods: Motivated by this potential, this study analysed associations between chronic pain and changes of large-scale brain network function using resting-state electroencephalography (EEG) from 614 individuals with chronic pain, collected by research groups from Australia, Germany, Israel, New Zealand, and the US.