Innovations to detect complications after heart- and lung transplantation

Overall, the aim of this thesis was to investigate novel innovations to detect complications a er heart and lung transplantation. Part I is the general introduction of this thesis and focusses on the current state of eNose technology in the eld of pulmonary medicine (Chapter 1). Part II explores the application of exhaled breath analysis using eNose technology for detecting complications following transplantation. Chapter 2 investigates the potential of eNose technology in lung transplantation. Chapter 3 examines whether eNose technology can di erentiate between complications, particularly acute cellular rejection and infection in lung transplant recipients. Chapter 4 assesses its accuracy in detecting chronic lung allogra dysfunction. Chapter 5 evaluates its potential for therapeutic drug monitoring of Tacrolimus trough levels. Chapter 6 explores the ability of eNose technology to detect bacterial colonization of the lung allogra . Finally, Chapter 7 investigates its use in identifying heart transplant recipients at risk for impaired glucose tolerance. Part III focuses on the exploration of home monitoring. Chapter 8 evaluates a home monitoring application for lung transplantation follow–up. Overall, the aim of this thesis was to investigate novel innovations to detect complications a er heart and lung transplantation. Part I is the general introduction of this thesis and focusses on the current state of eNose technology in the eld of pulmonary medicine (Chapter 1). Part II explores the application of exhaled breath analysis using eNose technology for detecting complications following transplantation. Chapter 2 investigates the potential of eNose technology in lung transplantation. Chapter 3 examines whether eNose technology can di erentiate between complications, particularly acute cellular rejection and infection in lung transplant recipients. Chapter 4 assesses its accuracy in detecting chronic lung allogra dysfunction. Chapter 5 evaluates its potential for therapeutic drug monitoring of Tacrolimus trough levels. Chapter 6 explores the ability of eNose technology to detect bacterial colonization of the lung allogra . Finally, Chapter 7 investigates its use in identifying heart transplant recipients at risk for impaired glucose tolerance. Part III focuses on the exploration of home monitoring. Chapter 8 evaluates a home monitoring application for lung transplantation follow–up. Overall, the aim of this thesis was to investigate novel innovations to detect complications a er heart and lung transplantation. Part I is the general introduction of this thesis and focusses on the current state of eNose technology in the eld of pulmonary medicine (Chapter 1). Part II explores the application of exhaled breath analysis using eNose technology for detecting complications following transplantation. Chapter 2 investigates the potential of eNose technology in lung transplantation. Chapter 3 examines whether eNose technology can di erentiate between complications, particularly acute cellular rejection and infection in lung transplant recipients. Chapter 4 assesses its accuracy in detecting chronic lung allogra dysfunction. Chapter 5 evaluates its potential for therapeutic drug monitoring of Tacrolimus trough levels. Chapter 6 explores the ability of eNose technology to detect bacterial colonization of the lung allogra . Finally, Chapter 7 investigates its use in identifying heart transplant recipients at risk for impaired glucose tolerance. Part III focuses on the exploration of home monitoring. Chapter 8 evaluates a home monitoring application for lung transplantation follow–up. Part IV comprises the general discussion, which examines the key ndings and challenges of this thesis. It also explores their implications for future research and potential integration into routine clinical practice.