Coronary artery disease prediction based on systemic arteries infliction

Coronary Artery Disease Prediction Based on Systemic Arteries Infliction Ischemic heart disease (IHD) remains one of the leading causes of morbidity and mortality in developed countries. Its prevention and diagnosis are traditionally based on risk prediction derived from the concept of cardiovascular risk factors. However, even contemporary risk models demonstrate limited performance in certain population subgroups, particularly in women, younger individuals, and patients with diabetes. Given the systemic nature of atherosclerosis, alternative approaches based on atherosclerosis-related biomarkers have therefore been explored, including the prediction of IHD through detection of systemic arterial infliction. The aim of this work was to evaluate, through three complementary studies, the contribution of selected structural and functional markers of peripheral arterial disease to the prediction of the presence and phenotype of IHD and to interpret these findings within the context of vascular physiology and pathophysiology. The first, retrospective study assessed the relationship between breast arterial calcifications (BAC) detected on mammography and the presence and severity of IHD in women undergoing invasive coronary angiography. Although the presence of BAC was not independently associated with IHD after...