Analysis of genetic factors associated with the effectivness of the spa therapy in obese children

Introduction: Obesity represents a major public health issue with a rising prevalence among both adults and children. Its etiopathogenesis is multifactorial, involving interactions of genetic, environmental, and socioeconomic factors that influence body fat accumulation and the resistance of fat stores to reduction interventions. Genetic predisposition accounts for approximately 40-70% of body weight regulation. Research into the genetic background of obesity, particularly through genome-wide association studies (GWAS), has identified over a thousand loci associated with obesity, many confirmed also in children. The increasing prevalence of childhood obesity indicates that knowledge of genetic factors alone is insufficient to address the existing problem. Growing attention is therefore directed toward examining how genetic predispositions affect the success of weight-reduction interventions, which may support the development of more effective therapeutic strategies. This thesis builds on previous research and expands current knowledge by analyzing the influence of selected genetic variants on the effectiveness of a short-term lifestyle intervention in obese pediatric patients. Aim: The primary aim of this thesis is to analyze the influence of the genetic variants SLC39A8 (rs13107325), SEC16B...