Neoadjuvant intraperitoneal, systemic, and oral chemotherapy in the conversion to curative-intent surgery for patients with advanced gastric cancer and synchronous peritoneal metastases
Abstract
Background: Outcomes of patients with peritoneal metastases from gastric cancer (GCPMs) remain dismal, with an overall survival (OS) of less than 1 year. Several approaches reported from East Asia include normothermic intra- peritoneal systemic () chemotherapy, aimed at downstaging the disease, allowing an R0 resection. This is the first Western study evaluating a bidirectional regimen in a neoadjuvant setting of GCPMs. This phase II study evaluates tolerability, efficacy and conversion surgery rate. Methods: Patients with PCI
Fields of Study & Subjects
Intraperitoneal and Appendiceal Malignancies
Gastric Cancer Management and Outcomes
Intestinal and Peritoneal Adhesions
Publication details
- Journal / source
- IRIS Research product catalog (Sapienza University of Rome)
- Publication date
- 20 January 2026
- Language
- EN
- Document type
- Thesis